Never shot a cartridge I didn't like.
I've shot some rifles that I absolutely hated.
It may be my bias but I have had a lot more trouble with accuracy and confidence and with the design of the firearm than I've ever had with the caliber or the cartridge. And.......... it's not just the manufacture of the rifle, it's the design.
I have Ssvage rifles that I love and shot great with, and the bullet kills what it hits, and others Savages that where mean and nasty and I couldn't kill crap and it wasn't the cartridge.
Same for Rugers, Winchesters, Browning and Remington. Same with muzzleloaders and shotguns.
I love or hate them all, depending on the fit and feel and where I can reliably put a bulllet, every time. For me it's all about where the bullet goes, not what cartridge it came out of. All I care about is accuracy. You'd be amazed what a .22 caliber cartridge bullet will do, if it hits a heart, lungs or brain, but its accuracy goes to hell, long before it's killing capacity goes.
But....... like everything else, my opinions reflect my personal bias.