Hornyman;
If this is going to be a deer-antelope rifle, I would go with the 25-06. It has the 243 beat hands down for average out of box accuracy, velocity, and flat shooting over long range. Yet it's recoil is still light. I have used the 25-06 as my deer-antelope rifle for over 20 years and I love it. I have made 6-8 one shot kills in excess of 400 yards out to 600 yards. The rifle has taken over 25 deer, muley & blacktail, whitetail, and 30 antelope and all were one shot kills except for two where I failed to do my part and placed the shot behind the lungs, gut shot, on running animals. I will not mentioned the 2 deer that I missed and shot over their back.
You have a good range of bullets from 75 grains to 120 grains, but I use only 117-120 grains for all of my deer-antelope shooting. I have shot many out of box 25-06 rifles and have found them all very accurate. Most would shoot under one inch without any tinkering, just finding the right load.
The reason I bought my first 25-06 over 20 years ago was the excellant write ups it was getting for accuracy in "out of box rifles". It is the only bolt action rifle that I have where I have not replaced the factory barrel with a custom match barrel. When the factory barrel shoots groups in the 1/2-3/4 inch group, no need to fix it.
Now when RLH jumps on this post and tell you that all calibers, except the 270, is a ##### caliber for non-men, do not listen to him. His name in his previous life was Jack O'Connor and he has a distorted view of calibers. He loves the 270 as much as I love the 25-06.
RELH