I would say that is sufficient out to 600 yards on elk. I love those bullets. The will penetrate anything, and a 165 will outperform any lead/copper jacket 180 grain every time. I would almost guarantee you on a broadside double lung shot through the ribcage at 400 yards would result in an exit.
I have seen no evidence that this penetration results in a lack of damage either. Wound channels seem large with as much internal damage as anything else I have seen.
They do also seem to shoot very accurately in everything.
I would not feel like you need to pick your shots at all. if you have to put it through a shoulder...do it, it will probably still exit.