Not scientific by any means but i killed a nice 28" 170 class 4x4 at over 10,000 ft elevation a couple seasons ago and i hit 4-5" higher than i expected.
I was locked in prone position, had ranged the buck at 360 yds. Was shooting a custom barreled Rem 700 in 280AI, 140 gr combined tech bullets built with 60 1/2 grs of imr 4350 that had crono'd at 3190 fps. 2 1/2" high at 100yds, dead on-to 1" low at 300, 8-9" low at 400 as shot from my make due, out of town range. Being the buck was uphill from my position but not excessivly so, i held for 300yds, middle to high shoulder, instead of allowing for 4-5" of drop if the 360yds were completely horizontal.
I was locked in tight, solid steady, and when the gun barked, i just knew that he was dust and he did drop dead on the spot. Surprised me very much and still a mystery to this day when i recovered the animal. i had hit 4-5" directly above expected, where the cross hairs had been when she barked. Altitude? It could maybe had something to do with it, good question.
joey