Man you seem to be way overthinking this.
I found the one bullet I can always get to shoot in tight groups very easily if I have a decent rifle is the TSX and TTSX.
Not a sensitive process either. Not sensitive to seating depth.
Downside to TSX is it flies like a turd, but unless your are shooting over 400 yds it's a non issue.
Kill's very well. It, like every other single bullet type, has certain weaknesses and should be used on game at the manufacturer's recommended min/max velocity for reliable expansion, but this is true of all bullet's including the Nosler family.
Bullet's are spendy, but worth it.