NVMDF, You just got to love a good shooting 25-06. I think everybody should have one. Of the 50-60 bucks i killed with that cartridge, about half were taken with soft point type bullets of less than 100 grains and you are correct, most of the time it is devastating.
I did have minor problems a couple times when i impacted bone right away and didn't get much penetration. Along with a serious entry hole and much local damage, there was bloodshot and bubbles all the way down to the hind quarters, back to belly. The bucks really weren't going anywhere after being hit but they took an additional shot to put them away. I found that though i had quite a bit less velocity with the heavier bullets, i had cleaner kills, especially on good muley bucks at farther ranges.
I too believe Nosler is on to something really good with their Accubond 110 grainer. I'm not in possession of a 25-06 at this time or that's what i'd be working up a load with.
Why not split the difference and go 25"? Either or any ol way you decide to go, Good luck with your project!!
Joey