I load those bullets in my 270 every once in a while. I get some of the best groups of any bullet out of that gun/bullet combo. there is a noticable reduction in recoil.
I would shoot anything up to a small deer with them, If if had a good broad side shot behind the ribs... I would not recommend them as a first choice hunting bullet, but you can count on all the energy being transfered into what ever they hit.
don't plan on selling any coyote hides, as the off side is pretty well gone.
I think I have used both IMR 4831 and RL 22 for powder. All differenet kinds of cases, and CCI 200 primers. In my gun it doesn't seem to matter they just shoot very good out of it. under an inch on a bad day.