They Work!
After I had my 300 wby glass bedded, I "tuned" my barrel with a de-resonator, and my groups went from 1 1/4 to 4/10ths @100 yds. (machine shot, computer measured)
I say "tuned", because you have to move them on your barrel until you find the sweet spot. Note: adding a muzzle break will change the harmonics of your barrel, and the de-resonator will have to be moved to account for this.
I would have never believed they could have such a positive effect on grouping if I had not been there when that first one was installed. I now have them on all my big game rifles. (My kids' too)
Keeping the de-resonator in the same spot is not an issue. Once it is on your barrel, you have to work it over pretty good to get it to move.
It would definitely be the FIRST thing I tried if I wanted to get tighter groups.
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"Yeah, I'll shoot him"