This is the first year I'll be missing the Muzzleloader season in Colorado in a few years. Love it. You're lucky, 21 is a trophy area, you could do really well.
If you're hunting out of Rangely, get up to Calamity ridge and hunt west of it (it's the east border of 21). There used to be a number of nice bucks up there. Wish I was huntin this year up there, nice folks in Rangely and a great place to hunt for sure. Best of luck to ya.