It depends, how much energy or momentum does your bow generate ?
What's more important to you, penetration or a big hole ? The ability to break through bone ?
If you're shooting 60 lbs or less, the first two heads on my list by Magnus are designed for superior penetration. They both have a superb reputation for sharpness and accuracy.
If you're shooting 65 lbs or more, the Magnus are still a top choice, but the Slick Trick, Shuttle and Wac Em have thick, solid steel ferrules that could easily break the heaviest bone. The Trick is a four blade head so it cuts more. The Shuttle has the best blade retention system I have ever seen. The Wac Em is available in both a 1 1/16? and the ?XL? version at 1 ?? if you want to make a really big hole.
Lot's to consider, one of these heads will be on my arrows this fall.