I've owned 6 Colt Pythons over the years and several Anacondas, Including one limited edition Colt Kodiak. The Colt Python right now is the most overpriced handgun on the market. That's what you get when a T.V. show (The Walking Dead) popularizes an out of production gun. Before TWD craze, Python prices were around $1,200-$1,500 and for me personally they were overpriced at that.
If you want a revolver with a fine lockwork that will be mostly a safe queen and pulled out for show and tell, shot occasionally, then the Python is a great handgun. If you want a gun that is going to be shot a lot and used on a regular basis, skip the Colt. Get a S&W or Korth.
Pythons are much more delicate and have a tendency to go out of time with lots of use. Try finding a gunsmith who truly knows his way around Colt revolvers these days. They are few and far between. Pythons had a lot of hand-fitting when they were produced and all of those Colt gunsmiths are long-retired now.
If you want one for an investment, you are late to the party. Colt started making revolvers again last year with the Colt Cobra (actual manufacturing is being outsourced) and rumors are they will expand the line.