What caliber of buck would make you happy? 160? 180? 260? If up to 180 would make you happy, then it's doable if you can put in some time scouting. Trying to scout right before the hunt is going to be hard to do. To effectively scout, you'll need to hit different areas, and trying to pack into one area for a couple days, then out and back in somewhere else the next, then do it a few more times, is really tough. The trails aren't overly steep, but in most areas you're still climbing 3k to 4k vertical feet. That's work, especially with all the gear needed to deal with weather. Snow is quite likely.
I would recommend trying to scout 3-4 different areas in the summer over a couple 6 day trips. I think if you can do that, you'll find a 180+ buck, maybe even 190+. If not, then hopefully there's one in whatever area you decide to hit. You just do the best you can. I'd imagine there's a 170-180 type buck in most areas, with "area" equaling 4 - 6 square miles of high country.
Just like everywhere, they become much harder to find in September than in July and August.
There's a lot of places in there where a big buck could be......no secret spots where all the big bucks live. It's sure awesome country though. Amazing place for backpacking......