Even if the second best buck area, holds a lot of pretty good bucks, you're probably only going to be hunting that one buck anyways, since you probably won't feel satisfied killing any of the lesser bucks in that area.
So if you're only technically hunting just one buck anyways, I'd go for the biggest buck you find. Even if there's less deer around. There could also be another hidden giant in that area. If one buck got that big in there, there could another that just wasn't out!
I literally have this exact scenario this year. Found an area with 15-20 bucks and 5 decent bucks that I'd probably be content with killing initially. Then I found a freaking hammer buck and now I'm just going to focus on him, because that's all I would be thinking about after I killed one of those lesser bucks in the other area anyways lol. And another giant could easily be tucked away also.
Just my thinking as I SLOWLY evolve into trying to kill big bucks lol. Probably still smoke the first decent 3x3 I turn up ?