Every once in a while, someone will kill a BIG buck out of the counties surrounding the canyon, but for the most part, personally I would shoot the first 150 class buck you see cuz that is as big as alot of them get up there. I have hunted in that same area several times and have never seen a huge deer by anyone's standards. One of my good friends owns a ranch that borders the Palo Duro Canyon State Park and the best he has ever killed is a 154.. Now the Whitetails up there are a diffrent story all together!!! Huge Whiteys up there!! Good luck on your hunt. I'll be in that part of the country in about 25 days on my antelope hunt in Hartley county.
Scottyboy
Go to the Texas Big Game Awards web site and there is a bunch of pics of deer from that region that were big enough to quailfy for the awards program. Good site for sure for a refrence on the qualty of bucks up there.