My Remington Model 7 SS in 7mm-08 was death and destruction on cows and spikes, and easy to carry all day in the timber! Never got to try it on a big bull. Hot handloads of IMR 4064 and 140 Nosler Solid Bases proved exceptional. I don't know why a 165 in a 308 wouldn't just be great also, especially if loaded hot like the above post mentioned.