Zacko,
I hail from a long line of 243 shooters and hunted the better part of my first 10 years with a 243 as my primary deer cartridge.... so I have a little experience to share.
First, I never lost a deer, which is more attributed to the Nosler partitions, which I used, than to my keen shooting. ha
I shot some Speer 90's and they were not tough enough at close range but worked well on longer shots. They were frangible when velocity was high and multiple hits were required, or so I presumed. Not what I want so I went back the the Partitions.
My wife has killed several bucks with an 85 gr Partition. bang/flop
I could go on and on but will stop with this; Pick a tough little bullet like the partition, place it through the ribs, avoid "raking" shots and you'll kill every deer at which you shoot out to as far as I should be shooting (about 400).
Zeke
PS: I think the Accubond would work well in a 243 but have only used then in other/larger calibers as I have moved away from the 243 as my primary deer rifle.