Bull, i shoot a couple flat shooting rigs with wind bucking abilities but have had to compensate more than a few times.
500 yds is about my self imposed limit on game animals, this has worked for me;
If a crosswind is barely blowing, i hold on or near so out to 200 then 1" for each additional 100 yds, out to 500yds.
When it's blowing cross at near 10 mph, i hold a couple inches out at 200yds and 2" more for each additional 100 yds, out to 500.
If it blowing like 20 mph or more, i'll hold off 4" at 200 yds and 4" for each additional 100 yds, out to 500.
So, with a 450 yd shot with a 20 mph cross wind, id hold, 4+4+4+2=14"
Have flat stoned some nice bucks using this rule of thumb but you got to sometimes go with your gut feelings for slight adjustments!
Joey